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. 2022 Dec 31;18(1):100772. doi: 10.1016/j.ajps.2022.100772

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© 2022 Shenyang Pharmaceutical University. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig 7 — Molecular mechanism of potential therapeutic effects of curcumin treated exosomes in OA treatment. (A) Morphology of exosomes derived from MSCs. (B) Schematic representation of the effects of curcumin treated MSC-derived exosomes on multiple signaling pathways. (C) The viability of primary chondrocytes after preparation treatment. (D) The expressions of ROCK1, TLR9 and NF-kB were analyzed by western blotting. (E) TUNEL detection of apoptosis in primary chondrocytes treated under different conditions. (F) Curcumin treatment of MSC-derived exosomes significantly reduced apoptosis. (G-H) Exosomes derived from MSCs treated with curcumin significantly inhibited the expression of ROCK1 and NF-kB proteins in primary chondrocytes treated with IL-1β. Reproduced from [92]. Copyright 2020 The Author(s).