Table 2.
Overall serum ferritin summary statistics under various conditions
| Study | Overall | Case/intervention | Control/comparator | Condition |
|---|---|---|---|---|
| Horvat [22] | 49 (17.2–153.3)p) | - | - | Hospitalized |
| Güngör [23] | - | 1,503.50±2,280.44 | 57.43±35.96 | Wilson disease |
| Papageorgiou [24]* | - | 48.61±36.63 | 74.03±38.04 | Febrile seizure |
| Turay [25]* | 28±32 | 41±54 | 22±16 | Febrile seizure |
| Higgins [26]* | 45±30 | - | - | HF secondary to dilated cardiomyopathy |
| Yang [27]* | 141.3(27.9–188.0) | 320 (98.8–619) | 38.7 (12.7–60.2) | IPH |
| Jacobs [28] | - | 117.6±16.2 | 134.4±27.6 | Bronchiolitis, anemia |
| Xu [29]* | - | 1,945±1,001 | 465±195 | Adenoviral pneumonia |
| Choi [30]* | - | 35.95a) | - | Mycoplasma pneumoniae pneumonia |
| Ling [31] | - | 421.61±341.06 | 150.85±167.70 | Mycoplasma pneumoniae pneumonia |
| Alshengeti [32] | 424.35±763.85 | - | - | COVID-19 |
| Astagimath [33] | 167.2±256.6 | - | - | COVID-19 |
| Jat [34] | 144 (80.1–290) | 397.9 (148–879.2) | 132 (80.1–196) | COVID-19 |
| Alfraij [35] | 1,229±1,689 | 587±796 | 1,358±1,807 | COVID-19 |
| Karimi [36]* | 413 (95–1,500) | 800 (800–2,037) | 125 (78–413) | COVID-19 in IEI |
| Clark [37]* | - | 171±57 | 678±107 | COVID-19 |
| Williams [38] | 668 (420–2,714) | 1,806 (443–4,727) | 666 (382–2,653) | Scrub typhus |
| Ellis [39] | - | 17,794 (754–522,000)a) | 4,139 (42–30,346) | Dengue |
| Allen [40] | - | 15,830 (994–189,721)a,c) | - | HLH |
| Goldman [41] | - | 47,500 (24,016–129,604)c) | 11,884 (3,130–36,602)c) | HLH |
| Mottaghipisheh [42]* | 4,825 (2,000.0–10,324.5) | 7,122 (3,226.2–33,112.2)a) | 3,618 (1,990.2–9,479.2) | HLH |
| Cui [43] | - | 35,803±5,826 | 36,290±6,205 | Secondary HLH |
| Demirkol [44] | 6,341 (765–100,000) | 40,802 (16,348–65,256)a) | 5,054 (765–100,000) | Secondary HLH, sepsis, MODS, MAS |
| Cattalini [45]* | - | 563.8 (250–1,068) | 227 (147–449) | KD |
| Pouletty [46]* | 1,067 (272–1,709) | 1,760 (1,693–2,500) | 295 (165–536) | Kawa-COVID-19 |
| Jinkawa [47] | - | 8,741±8,181.5 | - | MAS in KD |
| Pal [48] | 41,785±41,448 | - | - | MAS |
| Aydin [49]* | - | 17,863±21,846 | 753±586 | MAS due to sJIA, MIS-C |
| Minoia [50]* | - | 8,235 (2,048–22,977) | 900 (171–2,968) | sJIA |
| Penner [51] | 915 (475–1,650) | - | - | PIMS-TS |
| Sa [52] | - | 640 (1,400)c) | 549 (871)c) | MIS-C |
| Lee [53]* | - | 537a) | 4,594 | MIS-C |
| Pereira [54]* | - | 3,660 (469–35,976)a) | 3,295 (2,567–8,000) | MIS-C |
| Tiwari [55]* | 350 (170–733)c) | 1,178.0 (717.0–23,840.0)c) | 266.0 (153.0–555.0)c) | MIS-C |
| Torres [56] | 309 (156–696) | 542 (135–835) | 230 (156–298) | MIS-C |
| Valverde [57]* | 438 (420–846) | - | - | MIS-C |
| Abrams [58]* | 463 (225–911)c) | 626 (350–1,171)c) | 289 (156–529)c) | MIS-C |
| Atay [59]* | - | 1,200 (367–22,627) | 332.5 (16–3,274) | MIS-C |
| Klymet [60]* | - | 625 (103–8,433) | 310 (48.5–5,546) | MIS-C |
| Emeksiz [61]* | 535 (326.8–1,533.1) | 1,435 (445.5–1,744) | 438.5 (226.3–671.5) | MIS-C |
| Deep [62]* | - | 1,107 (393–2,668) | 426 (209–958) | MIS-C |
| Fitzgerald [63] | 60,214 (12,000–130,000)c) | - | - | Cytokine release syndrome |
| Simon [64]* | 2,025±6,233c) | 3,752±9,245c) | 874±2,369c) | Sepsis |
| Cui [65]* | - | 2,689 (1,554–7,142) | 1,025.2 (682.2–1,560) | Sepsis |
| Carcillo [66]* | - | 670 (240–2,610), 885 (285–3,205), 1,100 (390–4,770)c) | 200 (120–420), 185 (100–360)c) | Sepsis |
| Tonial [67]* | 172 (118.3–514) | 454.4±309.7 | 91.9±6 | Sepsis |
| Williams [68] | 798 (378–3,205) | 1,381 (433–5,410) | 707 (365–2,937) | Sepsis |
| Tonial [69]* | 149.5 (81.7–377.2)c) | 607 (217–1,251)c) | 138 (78–296)c) | Sepsis |
| Tonial [70]* | 150.5 (82.25–362) | 586 (226–1,093) | 138 (80.5–287) | Sepsis |
| Rasheed [71]* | 4,989.3±1,978.3 | 3,849.5±1,513.5 | 6,413.5±2,103.9 | Severe sepsis in transfusion dependent thalassemia |
| Ghosh [72] | 581 (287–1,283) | 763 (480–1,820) | 415 (262–852) | Septic shock |
| Garcia [73]* | 303 (21–2,210) | - | - | Severe sepsis, septic shock |
| Haiden [74] | - | 73.6 (34.3–99.9) | 97.5 (60.8–126.0) | Extremely low birth weight infants |
| Al-Ghananim [75] | 143±126 | - | - | Very low birth weight infants |
| Widness [76] | - | 351±55 | 310±32 | Very preterm, very low birth weight infants |
| Mäkelä [77] | - | 148.2 (100.7–218.2)b) | 239.5 (135.2–424.3) | Very preterm and preterm infants |
| Ram Mohan [78] | - | 244.853±187.334d) | 148.542±161.961d) | Neonates requiring resuscitation |
HF, heart failure; IPH, idiopathic pulmonary hemosiderosis; COVID-19, coronavirus disease 2019, IEI, inborn errors of immunity; HLH, hemophagocytic lymphohistiocytosis; MODS, multiple organ dysfunction syndrome; AKI, acute kidney injury; MAS, macrophage activation syndrome; KD, Kawasaki disease; sJIA, systemic juvenile idiopathic arthritis; MIS-C, multisystem inflammatory syndrome in children; PIMS-TS, pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus-2.
*
Statistical significance of ferritin measurement.
a)
Values are presented as median (range).
b)
Values are presented as the mean (95% confidence interval).
c)
Values are presented the peak.
d)
Values are presented as postintervention.