Table 3.
Condition-specific serum ferritin levels
| Study | Threshold (ng/mL) (normal range) | Proportion |
Condition | ||
|---|---|---|---|---|---|
| Increased (%) | Normal (%) | Decreased (%) | |||
| Al-Ghananim [75] | 15 | - | 100 | - | Very low birth weight infants |
| Widness [76] | 15 | - | 38.9 | Very preterm, very low birth weight infants | |
| Amin [79] | 76, 400 (76–400) | 18.6 | 53.6 | 21.4 | Very preterm infants |
| Ochiai [80]* | 500 | 13.6 | - | - | Very low birth weight infants |
| Papageorgiou [24] | 30 | - | - | 14 | Febrile seizure |
| Güngör [23] | 93.5a) (31–99) | - | - | - | Wilson’s disease |
| Higgins [26] | 100 | - | - | 92.9 | HF secondary to dilated cardiomyopathy |
| Ling [31]* | 171.15 (ROC), 174.15 (logistic regression)a) | - | - | - | Mycoplasma pneumoniae pneumonia |
| Choi [30] | 230a) | - | - | - | Mycoplasma pneumoniae pneumonia |
| Horvat [22] | 373a) | - | - | - | Hospitalized |
| Astagimath [33] | (male, 24–336; female, 11–307) | - | - | - | COVID-19 |
| Jat [34] | 60 (≤9 years), 300 (10–12 years) | 58.9 | - | - | COVID-19 |
| Alshengeti [32] | 500 (<500) | - | 85.7 | 14.3 | COVID-19 |
| Fernandes [81] | 500 | 51.2 | - | - | COVID-19, MIS-C |
| Hammad [82]* | 1,000 | 67.6 | - | - | COVID-19 in pediatric oncology |
| Pereira [54] | (36–91) | - | - | - | MIS-C |
| Emeksiz [61] | 140 (7–140) | - | - | - | MIS-C |
| Lee [53] | 200 | 86 | - | - | MIS-C |
| Valverde [57] | 200 (50–200) | 79 | - | - | MIS-C |
| Penner [51] | 300 (15.1–70.0) | - | - | - | PIMS-TS |
| Tiwari [55] | 300 | 54 | - | - | MIS-C |
| Balagurunathan [83]* | 500 | 42.9 | - | - | MIS-C |
| Acevedo [84]* | 500 | 50 | - | - | MIS-C |
| Deep [62]* | Per 100–unit increasea) | - | - | - | MIS-C |
| Ellis [39]* | 500 | 62.7 | - | - | Dengue |
| Mottaghipisheh [42] | 500 | 100 | - | - | HLH |
| Demirkol [44] | 500 | 100 | - | - | Secondary HLH/sepsis/MODS/MAS |
| Goldman [41]* | 10,000 | - | - | - | HLH |
| Allen [40] | 10,000 | - | - | - | HLH |
| Tonial [69] | 135a) | 40 | - | - | Sepsis |
| Tonial [67]* | 300 | - | - | - | Sepsis |
| Cui [65]* | 500 | - | - | - | Sepsis |
| Williams [68] | 500 (≤500) | 67.8 | 32.2 | - | Sepsis |
| Simon [64] | 1,210a) (≤1,000) | 38.9 | - | - | Sepsis |
| Carcillo [85] | 1,980a) | 13 | - | - | Severe sepsis |
| Garcia [73] | 500 (200–500) | 33.3 | 30.6 | 36.1 | Severe sepsis, septic shock |
| Ghosh [72] | 200 (50–300) | 63.9 | - | 36.1 | Septic shock |
| Minoia [50] | (18–300) | - | - | - | sJIA |
| Aydin [49] | 684 | - | - | - | MAS due to sJIA, MIS-C |
| Jinkawa [47] | 684 | 100 | - | - | MAS in KD |
| Pal [48]* | 50,000 (10–118) | - | - | - | MAS |
| Kurokawa [86]* | 1,000 | 37.7 | - | - | Allogeneic HCT |
| Pouletty [46] | 1,400a) | 85.7 | - | - | Kawa-COVID-19 |
| Williams [38] | 2,000a) (<500) | 72.6 | 27.4 | - | Scrub typhus |
| Bennett [87]* | 3,000 | 39.8 | - | - | ICU |
| Fitzgerald [63] | 4,984.4a) (≤500) | 46 | - | - | Cytokine release syndrome |
HF, heart failure; COVID-19, coronavirus disease 2019; MIS-C, multisystem inflammatory syndrome in children; PIMS-TS, pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus-2; HLH, hemophagocytic lymphohistiocytosis; MODS, multiple organ dysfunction syndrome; MAS, macrophage activation syndrome; sJIA, systemic juvenile idiopathic arthritis; KD, Kawasaki disease; HCT, hematopoietic cell transplantation; ICU, intensive care unit.
*
Statistical significance of ferritin measurement.
a)
Values are determined by analysis.