Figure 2.

Themes and dimensions related to impaired health-related quality of life (HR-QoL) in women with primary ovarian insufficiency (POI). Synthesizing the results of the scoping review identified potential targets for interventions to improve health-related quality of life (HR-QoL) in women with primary ovarian insufficiency (POI). (A) Three interacting themes (bold text in overlapping circles: diagnostic odyssey, isolation and stigma, ego integrity) contributed to impaired HR-QoL in women with POI (i.e. anxiety, depression, psychological distress, diminished health status). Dimensions for each theme are depicted by bullets. (B) Several mitigating factors were identified from the literature and are categorized at the individual, interpersonal and healthcare system levels. Protective factors are noted by bulleted points for each respective level. Dx, diagnosis.