REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit polyclonal to alpha smooth muscle Actin	Abcam	Cat#ab5694; RRID:AB_2223021
Goat Anti-Type I Collagen-UNLB	SouthernBiotech	Cat#1310-01; RRID:AB_2753206
Glyceraldehyde-3-phosphate dehydrogenase	Santa Cruz Biotechnology	Cat# sc-25778; RRID:AB_10167668
Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)	Cell Signaling Technology	Cat#9101; RRID:AB_331646
Phospho (Thr558) Moesin	Santa Cruz Technology	Cat#sc-12895; RRID:AB_2148235
Biological samples
Human liver biopsy	University of Bonn	202/01; BioProject PRJNA844027
Human portal and hepatic venous blood samples	University of Bonn	029/13; 121/14
Human hepatic venous and arterial blood samples	University of Copenhagen	H-1-2011-151
Chemicals, peptides, and recombinant proteins
Captopril	Sigma-Aldrich	Cat#C4042
Losartan	Sigma-Aldrich	Cat#SML3317
Entresto	Novartis	PZN 11126514
Sacubitril	MedChemExpress	Cat#HY-15407A/CS-2514.Batch n°:15499
Valsartan	ChemCruz	Cat#sc-220362B
NPY recombinant protein	Abnova Corporation	Cat#H00004852-P02
C-terminal peptide 1 NPY (20–36)	GenScript	Cat#SC1208
C-terminal peptide 2 NPY (30–36)	GenScript	Cat#SC1208
Critical commercial assays
Cyclic AMP ELISA kit	Thermo Fisher Scientific	Cat#4412182
Human NPY ELISA kit	Millipore	Cat# EZHNPY-25K
Experimental models: Cell lines
Primary mouse hepatocytes	This paper	N/A
Primary mouse liver sinusoidal endothelial cells	This paper	N/A
Primary mouse hepatic stellate cells	This paper	N/A
Primary mouse Kupffer cells	This paper	N/A
Experimental models: Organisms/strains
Mice: WT C57Bl/6J	Charles River	RRID:IMSR_JAX:000664
Mouse: Nep−/− (Lu et al.)43	Kindly provided by Prof. Thomas Walther, University College Cork, Cork, Ireland, Great Britain	N/A
Oligonucleotides
Acta2 (Mm00725412_s1)	Thermo Fisher Scientific	Cat#4331182
Col1a1 (Mm00801666_g1)	Thermo Fisher Scientific	Cat#4331182
Nep (MME) (Mm00485028_m1)	Thermo Fisher Scientific	Cat#4331182
Npyr1 (Mm00650798_g1)	Thermo fisher Scientific	Cat#4331182
Npyr1 (Hs00702150_s1)	Thermo Fisher Scientific	Cat#4331182
Software and algorithms
GraphPad Prism 9.5.0	GraphPad Software	https://www.graphpad.com/
ImageJ	ImageJ Software	https://imagej.nih.gov/ij/