REAGENT or RESOURCE	SOURCE	IDENTIFIER
Bacterial and virus strains
Phage Strains, see Table S1	This work	N/A
Bacterial Strains, see Table S2	This work	N/A
Chemicals, peptides, and recombinant proteins
ADNasa TURBO™	TermoFisher Scientific	Cat#AM2238
Benzonase® Nuclease	Sigma	Cat#70664–3
Micrococcal nuclease	New England Biolabs	Cat#M0247S
Proteinase K Solution (20 mg/mL)	Fisher Scientific	Cat#10259184
Zwittergent 3–10	Sigma	Cat#693021
Citric acid monohydrate	Sigma	Cat#C1909
Sodium tetraborate	Sigma	Cat#221732
3-hydroxybiphenyl	Sigma	Cat#262250
Glucuronic acid	Sigma	Cat#G5269
Critical commercial assays
Amicon Ultra-15 centrifugal filter units	Sigma	Cat#UFC910024
DNA Clean & Concentrator 5-Kit	Zymo	Cat#D4004
Invitrogen Qubit dsDNA HS Assay Kit	ThermoFisher Scientific	Cat#Q32851
Illumina Nextera XT DNA kit	Illumina	Cat#FC-131-1096
MiSeq Reagent Kit v2	Illumina	Cat#MS-102-2002
Deposited data
Phage killing curves	This work; Mendeley Data	https://doi.org/10.17632/c696dvvynf.2
Database of depolymerase sequences from literature	This work; Mendeley Data	https://doi.org/10.17632/c696dvvynf.2
List of phage receptors	This work; Mendeley Data	https://doi.org/10.17632/c696dvvynf.2
Review tropism of Klebsiella phages	This work; Mendeley Data	https://doi.org/10.17632/c696dvvynf.2
PDB files of phage RBPs from AlphaFold2	This work; Mendeley Data	https://doi.org/10.17632/c696dvvynf.2
Scripts for TPR calculation	This work; Mendeley Data	https://doi.org/10.17632/c696dvvynf.2
Software and algorithms
PRINSEQ	Schmieder and Edwards69	https://prinseq.sourceforge.net/
Unicycler v0.4.7	Wick et al.70	https://github.com/rrwick/Unicycler
SPAdes v.3.14	Bankevich et al.71	https://github.com/ablab/spades
apc script	N/A	https://github.com/tseemann/apc/blob/master/apc.pl
MIRA4	N/A	https://sourceforge.net/projects/mira-assembler/
FastANI	Jain et al.72	https://github.com/ParBLiSS/FastANI
VIRIDIC	Moraru et al.73	http://rhea.icbm.uni-oldenburg.de/VIRIDIC/
ape package	Paradis and Schliep74	http://ape-package.ird.fr/
Prokka v1.14	Seemann75	https://github.com/tseemann/prokka
Prokaryotic Virus Remote Homologous Groups (PHROGS)	Terzian et al.76	http://millardlab.org/2021/11/21/phage-annotation-with-phrogs/
genoplotR	Guy et al.77	https://genoplotr.r-forge.r-project.org/
Blast+	NCBI	ftp://ftp.ncbi.nlm.nih.gov/blast/executables/blast+
inphared	Cook et al.54	https://github.com/RyanCook94/inphared
bactaxR	Carroll et al.78	https://github.com/lmc297/bactaxR
ViPTreeGen	Nishimura et al.79	https://github.com/yosuken/ViPTreeGen
Kleborate	Wyres et al.43	https://github.com/katholt/Kleborate
Snippy	Seemann	https://github.com/tseemann/snippy
trimAl	Capella-Gutiérrez et al.80	http://trimal.cgenomics.org/
IQ-TREE2	Minh et al.81	https://github.com/iqtree/iqtree2
PhageBoost	Sirén et al.82	https://github.com/ku-cbd/PhageBoost
CRISPRCasTyper	Russel et al.83	https://crisprcas.i2bc.paris-saclay.fr/Home/Download
defense-finder	Tesson et al.32	https://github.com/mdmparis/defense-finder
PIRATE	Bayliss et al.84	https://github.com/SionBayliss/PIRATE
HMMER 3.1	Eddy85	http://hmmer.org/download.html
HH-suite3	Steinegger et al.86	https://github.com/soedinglab/hh-suite
InterProScan5	Jones et al.87	https://github.com/ebi-pf-team/interproscan
Phyre2	Kelley et al.88	http://www.sbg.bio.ic.ac.uk/∼phyre2/html/page.cgi?id=index
NGLVieweR	Rose et al.89	https://github.com/nvelden/NGLVieweR
Gget AlphaFold2	Luebbert and Pachter90	https://github.com/pachterlab/gget
MAFFT v7	Katoh and Standley91	https://mafft.cbrc.jp/alignment/software/
gggenomes	N/A	https://github.com/thackl/gggenomes
Gblocks	Castresana92	https://anaconda.org/bioconda/gblocks
seqtk	N/A	https://github.com/lh3/seqtk