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. 2022 Oct;26(Suppl 2):S77–S94. doi: 10.5005/jp-journals-10071-24326

Table 1.

Modified grade system for classification of quality of evidence and strength of recommendations for this guideline

Quality of evidence Level
Evidence from more than or equal to 1 good quality and well-conducted RCTs or meta-analysis of RCTs 1
Evidence from at least one RCT of moderate quality, well-designed clinical trial without randomization; or cohort or case-controlled studies 2
Evidence from descriptive studies, reports of expert committees, or opinions of respected authorities based on clinical experience 3
Not backed by sufficient evidence; however, a consensus reached by the working group, based on clinical experience and expertise UPP