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. Author manuscript; available in PMC: 2024 Feb 14.
Published in final edited form as: Immunity. 2023 Feb 14;56(2):433–443.e5. doi: 10.1016/j.immuni.2023.01.012

Figure 4. A limited number of polymorphisms in Pfs230D1 are found within potent transmission blocking epitopes.

Figure 4.

(A) Ten polymorphic residues were observed in 2,512 Pfs230D1 sequences from MalariaGen.net. Pfs230D1 is in gray surface and polymorphic residues are highlighted in red. The observed frequency is in parenthesis. (B) Surface representation of Pfs230D1 showing the binding epitope of 230AS-73 in salmon; (C) 230AL-37 in yellow; (D) 230AS-18 in gold; and (E) 230AL-18 in violet. N-terminal residue L557 are labelled as “N”. The orientation of Pfs230D1 in all panels is identical.