. Author manuscript; available in PMC: 2023 Mar 7.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2021 Oct 14;42(1):e48–e60. doi: 10.1161/ATV.0000000000000147

Table 1.

Priorities to Address Current Gaps in Knowledge

Determine how the genetic architecture of LPA accounts for differences in Lp(a) levels in different ancestry groups. Studies using properly processed samples and reliable methods for determining Lp(a) levels and apolipoprotein(a) isoform size will be required for this purpose.

Develop a complete understanding of apolipoprotein(a) synthesis and Lp(a) particle assembly by using sophisticated technologies, such as cryogenic electron microscopy.

Determine the mechanism(s) of Lp(a) clearance from the circulation and identify the key liver and extrahepatic receptors that are relevant to humans.

Lp(a) indicates lipoprotein(a).