In panel A, the middle lines in the box plots represent the median values, boxes represent the IQRs, whiskers extend to the most extreme observed values with 1.5 × the IQR of the nearer quartile, and dots represent observed values outside that range. Reference values may vary based on laboratory and location. LDL-C indicates low-density lipoprotein cholesterol; MI, myocardial infarction.
aChanges in total cholesterol, triglyceride, and high-density lipoprotein cholesterol levels over time are also presented in eFigure 1 in Supplement 2.