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. Author manuscript; available in PMC: 2023 Mar 7.
Published in final edited form as: ACS Nano. 2022 Jan 28;16(2):2494–2510. doi: 10.1021/acsnano.1c09108

Scheme 1: Summary of in vitro experimental results for particle sizes to be tested in the lethal injury model.

Scheme 1:

Sub-100 nm nanoparticles resulted in the greatest number of specifically bound platelets under flow; intermediate-sized nanoparticles resulted in the greatest number of platelets in a platelet-particle surface aggregate, and largest particles resulted in the greatest polymer mass accumulation onto platelet-particle surface aggregates. Adapted from Biorender 39.