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. 2023 Mar 7;14:1264. doi: 10.1038/s41467-023-36907-0

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — (a) SIVmac251-WY30 gp70 V1V2 antibody (week 0 control vs week 2 control P = ns; week 0 control vs week 0 tonsil MVA P = 0.0087; week 2 control vs week 0 tonsil MVA P = 0.0216; week 2 control vs week 2 tonsil MVA P = 0.0022; week 0 tonsil MVA vs week 2 tonsil MVA P = 0.0040). (b) SIVmac239-cs.23 gp70 (week 0 control vs week 2 control P = 0.0022; week 0 control vs week 0 tonsil MVA P = ns; week 2 control vs week 0 tonsil MVA P = 0.0022; week 2 control vs week 2 tonsil MVA P = 0.0040; week 0 tonsil MVA vs week 2 tonsil MVA P = 0.0022). (c) SIVsmE660-gp140 (week 0 control vs week 2 control P = ns; week 0 control vs week 0 tonsil MVA P = 0.0011; week 2 control vs week 0 tonsil MVA P = 0.0325; week 2 control vs week 2 tonsil MVA P = 0.0011; week 0 tonsil MVA vs week 2 tonsil MVA P = 0.0011), and (d) SIVsmE660-BR-CG7V gp70 (week 0 control vs week 2 control P = ns; week 0 control vs week 0 tonsil MVA P = 0.0022; week 2 control vs week 0 tonsil MVA P = 0.0022; week 2 control vs week 2 tonsil MVA P = 0.0022; week 0 tonsil MVA vs week 2 tonsil MVA P = 0.0040). specific antibody responses in control (n = 6) and tonsil vaccinated (n = 6) animals at 0 and 2 weeks post infection. Data are presented as mean values + /– standard error. Statistical analysis was performed using one-tailed Mann–Whitney U test and a P < 0.05 (*) was considered significant. * indicate P < 0.05. Error bars represent standard error.