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. 2023 Mar 7;14:1264. doi: 10.1038/s41467-023-36907-0

Fig. 8. Tonsil vaccination induced significant levels of SIVmac239-gag specific poly-functional CD8 T cell responses in peripheral blood.

Fig. 8

Qualitative analysis of SIVmac239-gag specific IFNγ, IL-2, and TNFα expression in peripheral blood (a) CD4 and (b) CD8 T cells of control (n = 6) and tonsil vaccinated (n = 6) animals at 2 weeks post infection. Frequency of (c) CD3+CD4+ T cells and (d) CD3+CD8+ T cells in peripheral blood of control (n = 6) and tonsil vaccinated (n = 6) animals that express IFNγ, IL-2, and TNFα at 2 weeks post infection. Statistical analysis was performed using two-sided Wilcoxon rank sum test in SPICE software and a P < 0.05 (*) was considered significant. * indicate P < 0.05. Error bars represent standard error.