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. 2023 Mar 7;12:28. doi: 10.1186/s40164-023-00381-7

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 10 — Injection of nutlin-3a/apcin alone or in combination was safe and tolerable in vivo. A The changes of mice body weight in the control group, the nutlin-3a group, the apcin group, and the nutlin-3a plus apcin group after treatment. ns meant P > 0.05. B Representative HE images of mice heart, liver, and kidney tissues in the four groups (× 200 magnification; scale bar, 100 μm). C Comparison of relevant indexes of the blood biochemistry test among the four groups. ns meant P > 0.05 compared with the control group. D Comparison of relevant indexes of the blood routine test among the four groups. ns meant P > 0.05 compared with the control group