Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 7;24:43. doi: 10.1186/s13059-023-02872-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 2 — An overview of the effector proteins and molecular functions of m⁶A and m⁵C. a Effector proteins and molecular functions of m⁶A and m⁵C in Arabidopsis. m⁶A is deposited to its target transcripts mainly by a multicomponent m⁶A methyltransferase complex in the nucleus. This complex could be divided into two subcomplexes, namely the m⁶A-METTL Complex (MAC) and the m⁶A-METTL Associated Complex (MACOM). Upon blue light treatment, MTA, MTB, and FIP37 are recruited to the CRY2 nuclear bodies for m⁶A methylation of several central oscillator genes. Another known m⁶A methyltransferase FIO1 acts separately to deposit m⁶A in a subset of transcripts. m⁶A is removed by ALKBH10B in the nucleus or by ALKBH9B in stress granules (SGs) in the cytoplasm. m⁶A is recognized by CPSF30L in the nucleus or ECT2/3 in the cytoplasm. m⁵C is catalyzed by TRM4B. RNA modifications affect RNA metabolism in many aspects, including (1) alternative polyadenylation, (2) translation, (3) RNA secondary structure, (4) RNA stability, (5) RNA localization, and (6) RNA transport. b Some known effector proteins of m⁶A and m⁵C in crops. Created with Biorender.com