Table 1.
Study | Distribution of concentrations | Comment |
---|---|---|
Wölfel et al. [31] | Stool samples occur in a range between below LoD to about 7.5 log10 copies per swab Average 6.76 × 105 copies per throat/nasal swab; max 7.11 × 108 |
Observations from hospitalised patients Decline in concentration over time |
Ahmed et al. [1] | Uniform (2.56, 7.67) log10 gc/g | Based on [31] |
Curtis et al. [34] | Between 100 and 7.1 × 108 gc/g | Based on [31] |
Lui et al. [43] | Between 3 and 6.2 log10 gc/ml Median 4.1 |
Observations from hospitalised patients |
Han et al. [44] | Between LoD and 10.3 log10 gc/ml Median 7.63 |
Observations from mildly symptomatic and asymptomatic children |
Medema et al. [12] | Gamma (10.78, 0.46) mean = 4.95, s.d. 1.5 log10 gc/g |
Based on five publications |
Miura et al. [41] | Mean 3.4 (95% CrI 0.24–6.5) log10 gc/g over the whole shedding period Peak concentration 6.5 (95% CrI 5.6–7.4) log10 gc/g |
Based on [31] and a fitted dynamical model for decline over time |
Chavarria-Miró et al. [45] | Between 3 and 7 log10 gc/g Mean first 10 days 5.3, later 4.9 |
Based on [31] |
Li et al. [46] | Between 1 and 8 log10 gc/g Mean: 4.23, s.e. 0.133 |
From systematic review |
Schmitz et al. [47] | Between 5.74 and 8.28 log10 gc/g Mean: 7.39, s.e. 0.67 Median: 6.64 |
Observations from student dormitories |
McMahan et al. [28] | Normal (7.6,0.8) log10 gc/g faeces after 5 days; Normal (3.5,0.35) log10 gc/g faeces after 25 days |
Based on [31] Dynamical model includes change in concentration over time |
LoD, limit of detection.