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. 2023 Feb 1;151:e28. doi: 10.1017/S0950268823000146

Table 1.

Reported distributions of the concentration of RNA copies (gene copies, gc) in human faeces (Cfaeces)

Study Distribution of concentrations Comment
Wölfel et al. [31] Stool samples occur in a range between below LoD to about 7.5 log10 copies per swab
Average 6.76 × 105 copies per throat/nasal swab; max 7.11 × 108
Observations from hospitalised patients
Decline in concentration over time
Ahmed et al. [1] Uniform (2.56, 7.67) log10 gc/g Based on [31]
Curtis et al. [34] Between 100 and 7.1 × 108 gc/g Based on [31]
Lui et al. [43] Between 3 and 6.2 log10 gc/ml
Median 4.1
Observations from hospitalised patients
Han et al. [44] Between LoD and 10.3 log10 gc/ml
Median 7.63
Observations from mildly symptomatic and asymptomatic children
Medema et al. [12] Gamma (10.78, 0.46)
mean = 4.95, s.d. 1.5 log10 gc/g
Based on five publications
Miura et al. [41] Mean 3.4 (95% CrI 0.24–6.5) log10 gc/g over the whole shedding period
Peak concentration 6.5 (95% CrI 5.6–7.4) log10 gc/g
Based on [31] and a fitted dynamical model for decline over time
Chavarria-Miró et al. [45] Between 3 and 7 log10 gc/g
Mean first 10 days 5.3, later 4.9
Based on [31]
Li et al. [46] Between 1 and 8 log10 gc/g
Mean: 4.23, s.e. 0.133
From systematic review
Schmitz et al. [47] Between 5.74 and 8.28 log10 gc/g
Mean: 7.39, s.e. 0.67
Median: 6.64
Observations from student dormitories
McMahan et al. [28] Normal (7.6,0.8) log10 gc/g faeces after 5 days;
Normal (3.5,0.35) log10 gc/g faeces after 25 days
Based on [31]
Dynamical model includes change in concentration over time

LoD, limit of detection.