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. Author manuscript; available in PMC: 2023 Mar 7.
Published in final edited form as: Nitric Oxide. 2018 Mar 14;76:62–70. doi: 10.1016/j.niox.2018.03.007

Fig. 1: Bone remodeling by osteoblasts and osteoclasts:

Fig. 1:

Osteoclasts differentiate from hematopoietic precursors under the influence of RANKL, which is secreted by osteoblasts together with its antagonist OPG. Osteoclasts resorb calcified bone matrix and recruit osteoblasts to fill the defect with new bone. Osteoblasts differentiate from mesenchymal stem cells and secrete extracellular matrix to form osteoid. Osteoid calcifies to form mature bone and surrounds mature osteocytes.