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. Author manuscript; available in PMC: 2023 Mar 7.
Published in final edited form as: Nitric Oxide. 2018 Mar 14;76:62–70. doi: 10.1016/j.niox.2018.03.007

Fig. 3: NO/cGMP signaling in fluid shear-stressed osteoblasts.

Fig. 3:

Shear stress activates NOS via increased calcium. Membrane-bound PKG2 activates integrin-bound Src to stimulate Erk and Akt, which regulate osteoblast proliferation, survival, and differentiation via BAD phosphorylation and increased fos- and β-catenin-controlled genes. PKG1α directly phosphorylates and inactivates BAD to promote survival.