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. Author manuscript; available in PMC: 2023 Mar 7.
Published in final edited form as: FEBS J. 2021 May 24;289(5):1315–1328. doi: 10.1111/febs.15963

Figure 4. Intersection of oncohistone mutations with developmental lineages and oncogenic partner mutations.

Figure 4.

A. Oncohistone mutations occurring in high-grade gliomas follow a specific temporal and regional pattern with specific oncogenic partners, consistent with a distinct cell-of-origin.

B. Murine models of H3.3 K27M using different techniques and in combination with oncogenic partner mutations, to achieve similarity with H3.3 K27M high-grade gliomas.