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. 2023 Mar 7;8:104. doi: 10.1038/s41392-023-01365-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — CD47-SIRPα pathway. a CD47 expressed on tumor cells interacts with SIRPα expressed on macrophages and other phagocytes to avoid immune surveillance. b Targeting CD47 or blocking the CD47-SIRPα axis interrupts their interaction and allows macrophages to phagocyte tumor cells. c CD47 expressed on hematopoietic cells or red blood cells interacts with SIRPα expressed on macrophages and other phagocytes to avoid phagocytosis. d Targeting CD47 or interrupting the CD47-SIRPα axis allows macrophages to phagocyte hematopoietic cells and thus brings the side effects such as anemia