TABLE 1.

Examples of the effect of inflammatory mediators on mRNA expression of predominant CYP isoforms.

Inflammatory mediator	Model	CYP isoform mRNA expression	References
TNF-α	TNF-α challenge of human hepatoma cell line (FLC-4)	CYP3A4 (↓51%)	(72)
IL-6	IL-6 challenged human—HepaRG cells	CYP1A2 (↓90%), CYP2C9 (↓83%), CYP2D6 (↓50%), CYP2C19 (↓83%), CYP3A4 (↓93%)	(53)
IL-2	IL-2 challenged in human hepatocytes	CYP3A4 (↓70–90%)	(64)
IL-2	IL-2 infusion in patients with hepatic metastasis	CYP1A2 (↓63%), CYP2C (↓55%), CYP2E1 (↓40%), CYP3A (↓61%)	(73)
IL-1β	IL-1 β challenge in human hepatocytes cell culture	CYP1A2 (NS), CYP2B6 (NS), CYP2C9 (NS), CYP3A4 (↓95%)	(63)
IL-1β	IL-1 β challenged in human—HepaRG cells	CYP3A4 (↓97%), CYP1A2 (↓93%), CYP2C9 (↓90%), CYP2C19 (↓93%), CYP2E1 (↓73%)	(52)

NS, no significant change.