Table 1.
Baseline sociodemographic and clinical features of the STAR*D genetics/sexual dysfunction Caucasian cohort (n = 1473)
| Normal | Impaired | Total | p | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Mean | SD | n | Mean | SD | n | Mean | SD | t | ||
| (a) Erectile function | |||||||||||
| Age (years) | 363 | 42.5 | 13.5 | 211 | 47.8 | 12.3 | 574 | 44.4 | 13.3 | −4.71 | <0.001 |
| Onset age (years) | 363 | 26.8 | 14.6 | 209 | 27.3 | 16.0 | 572 | 27.0 | 15.1 | −0.40 | 0.686 |
| Illness duration (years) | 363 | 15.7 | 13.2 | 209 | 20.4 | 15.0 | 572 | 17.5 | 14.1 | −3.88 | <0.001 |
| Episode duration (months) | 358 | 23.3 | 54.4 | 210 | 32.1 | 65.4 | 568 | 26.6 | 58.8 | −1.71 | 0.088 |
| QIDS-C (base) | 363 | 15.8 | 3.1 | 210 | 16.4 | 3.4 | 573 | 16.0 | 3.2 | −2.25 | 0.025 |
| CIRS-total severity (base) | 363 | 4.2 | 3.7 | 211 | 6.3 | 4.5 | 574 | 4.9 | 4.1 | −6.16 | <0.001 |
| n | % | n | % | n | % | χ2 | p | ||||
| Gender (male) | 363 | 100.0 | 211 | 100.0 | 574 | 100.0 | NA | NA | |||
| Married (yes) | 165 | 45.5 | 107 | 50.7 | 272 | 47.4 | 1.48 | 0.224 | |||
| Recurrent (yes) | 258 | 75.0 | 151 | 78.2 | 409 | 76.2 | 0.71 | 0.398 | |||
| Anxious (yes) | 131 | 38.3 | 106 | 53.5 | 237 | 43.9 | 11.81 | 0.001 | |||
| Setting (specialty) | 243 | 66.9 | 128 | 60.7 | 371 | 64.6 | 2.30 | 0.129 | |||
| Normal | Decreased | Total | p | ||||||||
| (b) Libido | n | Mean | SD | n | Mean | SD | n | Mean | SD | t | |
| Age (years) | 674 | 43.0 | 14.3 | 799 | 42.4 | 12.9 | 1473 | 42.7 | 13.5 | 0.83 | 0.408 |
| Onset age (years) | 671 | 26.7 | 15.2 | 793 | 25.1 | 14.4 | 1464 | 25.8 | 14.8 | 1.96 | 0.050 |
| Illness duration (years) | 671 | 16.4 | 14.2 | 793 | 17.2 | 13.9 | 1464 | 16.9 | 14.0 | −1.14 | 0.253 |
| episode duration (months) | 671 | 24.4 | 55.4 | 793 | 23.1 | 51.8 | 1464 | 23.7 | 53.5 | 0.44 | 0.661 |
| QIDS-C (base) | 673 | 15.8 | 3.3 | 797 | 16.4 | 3.3 | 1470 | 16.1 | 3.3 | −3.49 | <0.001 |
| CIRS-total severity (base) | 674 | 4.5 | 3.9 | 799 | 4.8 | 3.9 | 1473 | 4.7 | 3.9 | −1.36 | 0.175 |
| n | % | n | % | n | % | χ2 | p | ||||
| Gender (male) | 244 | 36.2 | 330 | 41.3 | 574 | 39.0 | 4.00 | 0.046 | |||
| Married (yes) | 228 | 33.8 | 440 | 55.1 | 668 | 45.3 | 66.56 | <0.001 | |||
| Recurrent (yes) | 479 | 75.2 | 583 | 78.8 | 1062 | 77.1 | 2.50 | 0.114 | |||
| Anxious (yes) | 268 | 41.3 | 346 | 45.4 | 614 | 43.5 | 2.34 | 0.126 | |||
| Setting (specialty) | 371 | 55.0 | 470 | 58.5 | 841 | 57.1 | 2.13 | 0.144 | |||
| Normal | Impaired | Total | p | ||||||||
| (c) Orgasm | n | Mean | SD | n | Mean | SD | n | Mean | SD | t | |
| Age (years) | 948 | 44.2 | 13.5 | 525 | 39.9 | 13.2 | 1473 | 42.7 | 13.5 | 5.92 | <0.001 |
| Onset age (years) | 941 | 27.0 | 15.3 | 523 | 23.8 | 13.5 | 1464 | 25.8 | 14.8 | 3.90 | <0.001 |
| Illness duration (years) | 941 | 17.3 | 14.4 | 523 | 16.1 | 13.3 | 1464 | 16.9 | 14.0 | 1.63 | 0.103 |
| Episode duration (months) | 942 | 25.5 | 58.1 | 522 | 20.4 | 43.8 | 1464 | 23.7 | 53.5 | 1.77 | 0.076 |
| QIDS-C (base) | 946 | 16.0 | 3.3 | 524 | 16.4 | 3.4 | 1470 | 16.1 | 3.3 | −1.77 | 0.078 |
| CIRS-total severity (base) | 948 | 4.9 | 4.0 | 525 | 4.3 | 3.5 | 1473 | 4.7 | 3.9 | 3.03 | 0.003 |
| n | % | n | % | n | % | χ2 | p | ||||
| Male | 302 | 31.9 | 272 | 51.8 | 574 | 39.0 | 56.56 | <0.001 | |||
| Married (yes) | 398 | 42.0 | 270 | 51.4 | 668 | 45.3 | 12.16 | <0.001 | |||
| Recurrent (yes) | 668 | 75.8 | 394 | 79.4 | 1062 | 77.1 | 2.35 | 0.125 | |||
| Anxious (yes) | 396 | 43.2 | 218 | 44.0 | 614 | 43.5 | 0.07 | 0.794 | |||
| Setting (specialty) | 513 | 54.1 | 328 | 62.5 | 841 | 57.1 | 9.65 | 0.002 | |||
The table shows the baseline sociodemographic and clinical features of genotyped citalopram-treated subjects and association with erectile dysfunction (a), decreased libido (b), and difficulty achieving orgasm (c) following treatment. Bold values indicates p⩽0.05.