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. 2022 Oct 25;32(6):1032–1047. doi: 10.1093/hmg/ddac262

Figure 5.

Figure 5

Dysregulation of epithelial and stromal markers in Hnf1b mutant uteri. (A) Immunofluorescence staining of FOXL2 and PAX2 in samples at P0, P7 and 4 M. After birth, FOXL2 failed to be upregulated whereas PAX2 lost expression in mutant samples. (B) Immunofluorescence staining of SMA and VIM in samples at P0, P7 and 4 M. In mutants, SMA and VIM had reduced expression at P0 but were upregulated at P7. By 4 M, SMA showed the development of a thicker myometrium and VIM continued to be upregulated in the stroma (arrow) of mutant animals. VIM expression co-localized with SMA in both the inner circular (ICM) and OLM of control (asterisks) but not mutant (arrowheads) samples. Scale bar = 25 μm.