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. 2022 Oct 11;32(6):934–947. doi: 10.1093/hmg/ddac250

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Validation of target mRNA in fibroblasts. Target mRNA in fibroblasts were validated by qPCR. Results were normalized to yWHAZ and presented as fold-change calculated by the 2^-∆C_T method for GADD45 [C9-ALS, n = 5; Control (Ctrl), n = 6], IP6K2 (C9-ALS, n = 5; Ctrl, n = 6). Transcript stability was determined as the ratio between transcript abundance at 6 h (pulse/chase) to 0.5 h (pulse) and compared with Ctrl. Experiment performed in duplicate; analysis by Student’s t-test; data represented as mean ± standard error of the mean.