Table 2.
Top functions of differential miRNAs from fibroblasts
| Type | KEGG ID | Pathway description | #miRNAs | #genes | Adjusted P-value |
|---|---|---|---|---|---|
| C9-ALS | hsa05205 | Proteoglycans in cancer | 45 | 147 | 2.81E−10 |
| hsa04012 | ErbB signaling pathway | 44 | 71 | 1.18E−06 | |
| hsa04152 | AMPK signaling pathway | 45 | 99 | 1.30E−06 | |
| hsa04512 | ECM-receptor interaction | 38 | 57 | 5.98E−06 | |
| hsa04390 | Hippo signaling pathway | 46 | 109 | 6.24E−06 | |
| hsa00512 | Mucin type O-Glycan biosynthesis | 25 | 21 | 7.77E−06 | |
| hsa05200 | Pathways in cancer | 48 | 273 | 7.77E−06 | |
| hsa00061 | Fatty acid biosynthesis | 20 | 9 | 1.12E−05 | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | 46 | 103 | 1.23E−05 | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | 45 | 105 | 2.94E−05 | |
| hsa04915 | Estrogen signaling pathway | 43 | 71 | 5.11E−05 | |
| hsa04360 | Axon guidance | 45 | 95 | 5.11E−05 | |
| hsa04510 | Focal adhesion | 44 | 149 | 5.87E−05 | |
| hsa04015 | Rap1 signaling pathway | 46 | 151 | 5.87E−05 | |
| hsa04150 | mTOR signaling pathway | 44 | 51 | 6.26E−05 | |
| hsa05214 | Glioma | 44 | 49 | 6.26E−05 | |
| hsa04350 | TGF-beta signaling pathway | 41 | 59 | 7.58E−05 | |
| hsa04520 | Adherens junction | 44 | 59 | 7.58E−05 | |
| hsa05215 | Prostate cancer | 44 | 69 | 1.22E−04 | |
| hsa04151 | PI3K-Akt signaling pathway | 47 | 231 | 1.34E−04 | |
| nonC9-ALS | hsa00512 | Mucin type O-Glycan biosynthesis | 23 | 20 | 3.43E−07 |
| hsa05205 | Proteoglycans in cancer | 38 | 135 | 3.43E−07 | |
| hsa04012 | ErbB signaling pathway | 37 | 68 | 9.17E−07 | |
| hsa04360 | Axon guidance | 36 | 91 | 4.44E−06 | |
| hsa05032 | Morphine addiction | 36 | 65 | 5.11E−06 | |
| hsa04520 | Adherens junction | 39 | 58 | 6.67E−06 | |
| hsa05031 | Amphetamine addiction | 33 | 49 | 2.33E−05 | |
| hsa04152 | AMPK signaling pathway | 38 | 90 | 2.33E−05 | |
| hsa04014 | Ras signaling pathway | 41 | 153 | 2.79E−05 | |
| hsa04915 | Estrogen signaling pathway | 35 | 65 | 3.85E−05 | |
| hsa04727 | GABAergic synapse | 36 | 60 | 3.85E−05 | |
| hsa04724 | Glutamatergic synapse | 37 | 82 | 3.85E−05 | |
| hsa05231 | Choline metabolism in cancer | 38 | 76 | 7.47E−05 | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | 37 | 99 | 9.34E−05 | |
| hsa00310 | Lysine degradation | 33 | 34 | 1.29E−04 | |
| hsa05211 | Renal cell carcinoma | 35 | 52 | 1.43E−04 | |
| hsa05212 | Pancreatic cancer | 35 | 49 | 2.08E−04 | |
| hsa04015 | Rap1 signaling pathway | 38 | 140 | 2.84E−04 | |
| hsa05200 | Pathways in cancer | 40 | 261 | 3.13E−04 | |
| hsa04350 | TGF-beta signaling pathway | 31 | 56 | 3.71E−04 |