Table 3.
Top functions of differential miRNAs from WB
| Type | KEGG ID | Pathway description | #miRNAs | #genes | Adjusted P-value |
|---|---|---|---|---|---|
| C9-ALS | hsa05205 | Proteoglycans in cancer | 57 | 157 | 1.74E−08 |
| hsa04012 | ErbB signaling pathway | 54 | 72 | 3.40E−06 | |
| hsa05032 | Morphine addiction | 54 | 72 | 3.40E−06 | |
| hsa04390 | Hippo signaling pathway | 53 | 113 | 7.86E−06 | |
| hsa04727 | GABAergic synapse | 51 | 67 | 9.30E−06 | |
| hsa05200 | Pathways in cancer | 61 | 286 | 2.39E−05 | |
| hsa04360 | Axon guidance | 56 | 97 | 6.49E−05 | |
| hsa00512 | Mucin type O-Glycan biosynthesis | 31 | 22 | 6.57E−05 | |
| hsa00533 | Glycosaminoglycan biosynthesis—keratan sulfate | 17 | 12 | 8.38E−05 | |
| hsa05100 | Bacterial invasion of epithelial cells | 51 | 63 | 8.95E−05 | |
| hsa05211 | Renal cell carcinoma | 48 | 54 | 9.14E−05 | |
| hsa04520 | Adherens junction | 51 | 60 | 9.14E−05 | |
| hsa04120 | Ubiquitin mediated proteolysis | 52 | 106 | 9.14E−05 | |
| hsa04015 | Rap1 signaling pathway | 57 | 157 | 9.85E−05 | |
| hsa04350 | TGF-beta signaling pathway | 48 | 62 | 1.28E−04 | |
| hsa04068 | FoxO signaling pathway | 53 | 104 | 1.40E−04 | |
| hsa05033 | Nicotine addiction | 46 | 31 | 2.13E−04 | |
| hsa00310 | Lysine degradation | 48 | 38 | 2.28E−04 | |
| hsa04919 | Thyroid hormone signaling pathway | 55 | 90 | 2.28E−04 | |
| hsa04724 | Glutamatergic synapse | 56 | 86 | 2.75E−04 | |
| nonC9-ALS | hsa05032 | Morphine addiction | 30 | 68 | 1.57E−11 |
| hsa05205 | Proteoglycans in cancer | 34 | 140 | 4.15E−11 | |
| hsa04727 | GABAergic synapse | 28 | 63 | 3.95E−08 | |
| hsa04360 | Axon guidance | 33 | 92 | 4.79E−08 | |
| hsa04390 | Hippo signaling pathway | 33 | 102 | 4.79E−08 | |
| hsa04012 | ErbB signaling pathway | 34 | 68 | 4.79E−08 | |
| hsa04015 | Rap1 signaling pathway | 36 | 147 | 1.87E−07 | |
| hsa05200 | Pathways in cancer | 37 | 255 | 6.01E−07 | |
| hsa04014 | Ras signaling pathway | 37 | 150 | 1.33E−06 | |
| hsa00512 | Mucin type O-Glycan biosynthesis | 20 | 20 | 1.39E−05 | |
| hsa04724 | Glutamatergic synapse | 33 | 77 | 3.45E−05 | |
| hsa04510 | Focal adhesion | 35 | 139 | 3.52E−05 | |
| hsa04919 | Thyroid hormone signaling pathway | 35 | 81 | 4.76E−05 | |
| hsa04512 | ECM-receptor interaction | 27 | 51 | 5.02E−05 | |
| hsa05211 | Renal cell carcinoma | 27 | 50 | 7.22E−05 | |
| hsa05214 | Glioma | 28 | 46 | 9.21E−05 | |
| hsa05030 | Cocaine addiction | 26 | 34 | 1.47E−04 | |
| hsa04350 | TGF-beta signaling pathway | 29 | 53 | 1.47E−04 | |
| hsa04068 | FoxO signaling pathway | 32 | 91 | 1.47E−04 | |
| hsa05100 | Bacterial invasion of epithelial cells | 30 | 55 | 1.49E−04 |