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E3 ligases in cell cycle regulation. E3 ligases regulate cell cycle progression via regulating the CDK and cyclin activity at the four phases of the cell cycle. E3 ligases majorly act directly on Cyclins and mediate their ubiquitination and degradation, but for CDKs, E3 ligases act on the primary CDK regulators such as CDK inhibitors (p27, p21, p57), and mediate their ubiquitination and degradation.
