Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
E3 ligases in the regulation of pro‐survival/apoptosis switch. The E3 ligases TRAF2 and cIAP mediate ubiquitination in favour of pro‐survival complex I. The presence of deubiquitinases (CYLD and A20) promote the switch from pro‐survival complex I to apoptotic complex II. LUBAC stabilises the ubiquitin chain in complex I and prevents complex II formation. Several E3 ligases function as negative regulators of apoptotic caspases.
