Table 2.

Adverse reactions within 28 days after booster vaccination

	Aerosolised Ad5-nCoV group (n=117)	Intramuscular Ad5-nCoV group (n=120)	CoronaVac group (n=119)	p value*
Adverse reactions within 28 days
Total (any)	11 (9%)	36 (30%)	17 (14)	<0·0001
Grade 3	0	4 (3%)	0	0·019
Solicited administration-site adverse reactions
Total (any)	8 (7%)	27 (23%)	13 (11%)	0·0012
Redness† (any)	0	3 (3%)	0	0·083
Xerostomia (any)	6 (5%)	0	0	..
Oral ulcer (any)	1 (1%)	0	0	..
Itch† (any)	0	4 (3%)	4 (3%)	0·99
Hoarseness (any)	1 (1%)	0	0	−
Pain† (any)	0	26 (22%)	12 (10%)	0·014
Throat pain (any)	4 (3%)	0	0	..
Induration† (any)	0	4 (3%)	2 (2%)	0·41
Swelling† (any)	0	3 (3%)	0	0·083
Solicited systemic adverse reactions
Total (any)	8 (7%)	18 (15%)	6 (5%)	0·016
Nausea (any)	0	2 (2%)	1 (1%)	0·37
Fever (any)	1 (1%)	12 (10%)	0	<0·0001
Grade 3	0	4 (3%)	0	0·019
Muscle pain (any)	1 (1%)	4 (3%)	0	0·075
Diarrhoea (any)	1 (1%)	3 (3%)	2 (2%)	0·62
Joint pain (any)	0	3 (3%)	1 (1%)	0·18
Cough (any)	4 (3%)	2 (2%)	0	0·13
Runny nose (any)	3 (3%)	2 (2%)	1 (1%)	0·60
Vomiting (any)	1 (1%)	1 (1%)	0	0·60
Sneeze (any)	2 (2%)	1 (1%)	0	0·36
Fatigue (any)	2 (2%)	8 (7%)	2 (2%)	0·049
Headache (any)	3 (3%)	7 (6%)	1 (1%)	0·077
Thoracalgia (any)	1 (1%)	0	0	0·36
Loss of appetite (any)	0	1 (1%)	0	0·37
Throat pain (any)	0	1 (1%)	0	0·37
Unsolicited adverse reactions
Itchy pharynx (any)	1 (1%)	0	0	0·36

Data are n (%). Any=all the participants with any grade adverse reactions or events. The analysis was based on the intention-to-treat cohort.

^*Calculated with χ² test or Fisher's exact test.

^†p value shows the result of the comparison between the intramuscular Ad5-nCoV group and the CoronaVac group.