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. 2023 Feb 15;5(2):fcad030. doi: 10.1093/braincomms/fcad030

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Structural T1-weighted MRIs showing affected brothers BI (top row) at age 28 and BII (bottom row) at age 25. Mild atrophy is present only in the older brother with more advanced disease; atrophy was still minimal at autopsy at age 29.