Figure 7.

Immunohistochemistry of motor cortex in the patient with the F388S PSEN1 mutation and in an autosomal dominant Alzheimer’s disease control without spastic paraparesis. (A) Motor cortex shows amyloid plaques seen with Aβ42 immunostain in the index case with the F388S mutation in PSEN1 and (B) a patient with the V717I mutation in APP that does not cause SP (scale bar = 500 μm), (C) tau pathology in motor cortex with the F388S mutation (scale bar = 600 μm) and (D) with the V717I mutation (scale bar = 500 μm), tau pathology is not obviously more severe in the patient with SP.