Table 1.
ANOVA’s comparing clinical features, flortaucipir PET SUVRs and MD from DTI among the three brothers with the F388S PSEN1 mutation, eight persons with the A431E PSEN1 mutation (seven for flortaucipir PET) and three persons with autosomal dominant Alzheimer’s disease mutations not causing SP
| Persons with the F388S PSEN1 mutation (n = 3) | Persons with the A431E PSEN1 mutation (n = 8, 7 for tau PET) | Persons with autosomal dominant Alzheimer’s disease mutations not causing SP (n = 3) | ||
|---|---|---|---|---|
| Age in years | 25.7 (1.24) | 42.4 (3.3) | 56.7 (11.4) | P < 0.001* |
| Gender (# male) | 3 | 5 | 2 | |
| CDR sum of boxes | 7.5 (7.1) | 8.81 (4.27) | 3.67 (2.52) | P = 0.348 |
| Ashworth score in legs, | 3.5 (0.87) | 1.75 (1.28) | 0.0 (0.0) | P = 0.008* |
| SUVR, entorhinal cortex | 1.60 (0.51) | 3.85 (1.46) | 2.19 (0.92) | P = 0.045 |
| SUVR, precuneus | 5.41 (3.94) | 6.63 (3.20) | 2.78 (1.95) | P = 0.227 |
| SUVR, precentral gyrus | 4.29 (3.24) | 5.50 (4.11) | 1.50 (0.58) | P = 0.299 |
| SUVR, paracentral gyrus | 4.52 (3.38) | 5.18 (3.51) | 1.33 (0.22) | P = 0.244 |
| SUVR, pericalcarine cortex | 2.51 (1.65) | 2.70 (1.44) | 1.29 (0.18) | P = 0.340 |
| MD, corpus callosum | 0.00088 (0.000049) | 0.06887 (0.013520) | 0.013520 (0.022087) | P = 0.761 |
| MD, left CST | 0.000808 (0.000059) | 0.000719 (0.000040) | 0.000683 (0.000021) | P = 0.008* |
| MD, right CST | 0.000811 (0.000048) | 0.000733 (0.000033) | 0.000680 (0.000030) | P = 0.003* |
| MD, left precentral gyrus | 0.000676 (0.000068) | 0.000534 (0.000030) | 0.000498 (0.000020) | P < 0.001* |
| MD, right precentral gyrus | 0.000676 (0.000072) | 0.000538 (0.000014) | 0.000511 (0.000024) | P < 0.001* |
| MD, left paracentral lobule | 0.000683 (0.000077) | 0.000542 (0.000032) | 0.000507 (0.000031) | P = 0.001* |
| MD, right paracentral lobule | 0.000683 (0.000065) | 0.000556 (0.000027) | 0.000503 (0.000029) | P < 0.001* |
| MD, left entorhinal cortex | 0.000693 (0.000087) | 0.000594 (0.000037) | 0.000593 (0.000022) | P = 0.038 |
| MD, right entorhinal cortex | 0.000691 (0.000091) | 0.000600 (0.000035) | 0.000611 (0.000013) | P = 0.051 |
| MD, left precuneus | 0.000711 (0.000089) | 0.000592 (0.000033) | 0.000542 (0.000032) | P = 0.005* |
| MD, right precuneus | 0.000701 (0.000079) | 0.000602 (0.000024) | 0.000540 (0.000030) | P = 0.003* |
| MD, left pericalcarine | 0.000737 (0.000093) | 0.000607 (0.000017) | 0.000570 (0.000040) | P = 0.003* |
| MD, right pericalcarine | 0.000713 (0.000068) | 0.000604 (0.000022) | 0.000580 (0.000040) | P = 0.003* |
Measures in parentheses are standard deviations and bold-faced P-values (*) are those less than 0.01. Note that SUVRs are averages between the two hemispheres.