Fig. 8.

Performance on Cry1Ac dataset. (a) Mutant allele frequency trajectories over directed evolution for 528 hr. Performance on selection and fitness inference are plotted for methods (b) Evoracle, (c) nonlinear, and (d) SL, against inference results using true covariance information computed from sequences. The Evoracle result denotes selection inferred with covariance matrix computed from haplotype frequencies reconstructed by Evoracle. Evoracle and nonlinear methods provide more accurate inference for both selection and fitness than SL.