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. 2023 Feb 13;10(3):ofad069. doi: 10.1093/ofid/ofad069

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Published by Oxford University Press on behalf of Infectious Diseases Society of America 2023.

This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 4. — Relationship between the Hamming distance for spike from SARS-CoV-2 variants causing COVID-19 cases (vs spike from the mRNA-1273 vaccine SARS-CoV-2 strain) in (A) the placebo or (B) vaccine arm and binding antibody level (assessed by the 10-plex assay, see Supplementary Figure 4) at disease day 29. Each large dot is a mean value over all participants, each faded dot/faded line is from an individual participant. Abbreviations: AUC, area under the receiver operating curve; COVID-19, coronavirus disease 2019; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.