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Diagnostic work-up of relapse after allogeneic HSCT.
| Diagnostics | |
|---|---|
| Bone Marrow |
Morphology Blast % and promyelocytes % Flow cytometry and/or cytochemistry Cytogenetics (for Ph-positive and/or additional chromosomal aberrations) with a minimum of 15 metaphases analyzed Fluorescent-in-situ-hybridization (FISH) if marrow cytogenetics fails |
| Molecular genetics | Tyrosine kinase domain mutation analysis if BCR::ABL1 transcript level >1% |
| Cerebrospinal Fluid | Cytology |
