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. 2022 Dec 22;37(3):529–538. doi: 10.1038/s41375-022-01799-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Oncoplot showing the distribution of clinical features and genetic abnormalities within the ETV6::RUNX1-like subtype and associated copy number profile risk status (UKALL-CNA [36] and IKZF1_plus [40]). Coexistence of CRLF2-r is indicated in red in the B-other subtype row. Copy number profile status was unavailable for patients lacking Multiplex Ligation-dependent Probe Amplification (MLPA) data. *The SALSA P335-ALL-IKZF1 and P327-iAMP21-ERG MLPA kits were used to determine gene copy number. Relapses were defined as follows: very early, < 18 months from diagnosis; early, within 6 months of end of treatment; late > 6 months after end of treatment. B Circos plot illustrating the constellation of ETV6 translocation partner genes which characterise ETV6::RUNX1-like. Only the recurrent translocation partners are labelled with gene names. C Heatmap of MLPA ratios for copy number detection of ETV6 and IKZF1 across the ETV6::RUNX1-like subtype.