FIG. 1.

(A) Alignment between Neuralized proteins from Drosophila, mouse, and human. NHR-1 and NHR-2 are marked by a dashed line above the amino acid sequence, and identical residues are boxed. The Drosophila neuralized gene encodes a protein of 754 amino acids, while the human and mouse gene encode proteins of 574 and 557 amino acids, respectively. Neuralized proteins from all three organisms show significant sequence homology in the two NHR domains and in the ring finger (solid line). (B) Alignment of the Neuralized ring finger domain with ring finger domains of the IAP protein family. Sequences from human (h-IAP 1 and h-IAP 2), mouse (m-IAP 1 and m-IAP 2), and rat (r-IAP 2) are shown.