Figure 1.

Comparisons of viral kinetics between patients receiving nirmatrelvir/ritonavir and molnupiravir (A) and between patients with and without viral rebound (B). Panel A shows viral clearance rate, defined as the ratio of the difference between the value of Ct_highest and that of Ct_lowest to the interval between the detection date of Ct_highest and that of Ct_lowest. Of them, Ct_highest is the highest Ct value before rebound among patients with viral rebound and that during follow-up among those without viral rebound. Ct_lowest is the lowest Ct value within 5 days of index PCR test among patients with and without viral rebound. A boxplot displays median and interquartile range, and whiskers display minimum and maximum Ct values. Ct values above the upper limit of detection, 40, were assigned a value of ≥40. Patients with reverse viral decay kinetics were not included (1 in NMV/r group and 2 in MOV group). Panel B shows sequential median Ct values in patients with and without viral rebound by circles and diamonds, respectively. The difference of median Ct value between patients with and without viral rebound was approaching significantly on Day 10 after index RT-PCR. The I bars represent interquartile ranges. NMV/r, nirmatrelvir/ritonavir; MOV, molnupiravir.