Figure 2.

The symptom heatmaps of 11 COVID-19 patients experiencing viral rebound. The y axis represents each patient numbers, and the x axis represents days after index PCR. A symptom score, consisting of fever, headache/myalgia, malaise, cough/sputum, rhinorrhea/nasal congestion, sore throat/hoarseness, dyspnea, diarrhea, and dysosmia, was used for daily symptom evaluation among them. A score of each symptom is assigned as a value of 0–2, indicating asymptomatic, improving or mild, and progressive or persistent, respectively. A highest daily symptom score is 18. Each green bar illustrates the treatment course of each patient receiving oral antivirals. Each red square illustrates the date of viral rebound. Paired viral cultures at the date of viral rebound and at the most closely date prior to viral rebound were performed in 4 patients (P01, P04, P09, and P15). Additional viral cultures at different dates were performed in patient P15. A symbol of plus indicates replication-competent virus, and a symbol of cross indicates unculturable virus.