Figure 4:

Effects of HFrD early life exposure on Go/No-Go task performance. Schematic of the Go/No-Go paradigm design. The task comprised 3 phases designed to test learning, attention and impulsivity. Learning of the operant association lever pressing + reward (left panel) was assessed Kaplan-Meier survival curves showing the cumulative probability of adolescent HFrD males (●) and females (●) and control fed males (●) and females (●) subjects not achieving criterion across training sessions (middle panel) and the corresponding accuracy data (right panel) (A). Attentive behavior was assessed in phase 2 through cue discrimination during go trials (left panel), multiple comparisons indicate that HFrD males took significantly longer to reach criterion, had lower accuracy of response (middle panels) and presented a significantly higher average error rate (right panel) (B). Impulsivity was assessed through inhibitory control with the introduction of an auditory stop signal (phase 3) (left panel). Performances in phase 3 as measured by the accuracy of the responses on Go and No-Go trials revealed that HFrD males inhibited their planned response in No-Go trials significantly less than the other groups (right panel) (C). Single dots represent individual litters and bars are average mean ± SD of n = 12 litters/group. Asterisks indicate significant comparisons between groups *p < 0.05; **p < 0.01; ***p ≤ 0.001.