Table 1.
Patient demographics.
| Case | Affected/Unaffected | Age at onset | Age at death | Clinical Dx | Autopsy | Neuropathological findings |
|---|---|---|---|---|---|---|
|
| ||||||
| II-1 | Affected | ~65 | ~75 | bvFTD probable AD with CVD | Yes | FTLD-TDP, APBD, low ADNC, HS, ARTAG |
| II-2 | Unaffected | - | ~85 | - | No | - |
| II-3 | Affected | ~75 | ~85 | bvFTD | No | - |
| II-4 | Unaffected | - | ~75 | - | No | - |
| II-5 | Affected (Proband) | ~60 | ~75 | bvFTD | Yes | FTLD-TDP, APBD, high ADNC, HS, ARTAG |
| II-6 | Unaffected | - | ~85 | - | No | - |
Abbreviations; AD, Alzheimer’s disease; ADNC, Alzheimer’s disease neuropathologic change; APBD, adult polyglucosan body disease; ARTAG, Aging-related tau astrogliopathy; bvFTD, behavioural variant frontotemporal dementia; HS, hippocampal sclerosis.