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. Author manuscript; available in PMC: 2024 Mar 6.
Published in final edited form as: Angew Chem Int Ed Engl. 2023 Feb 6;62(11):e202211358. doi: 10.1002/anie.202211358

Figure 1.

Figure 1.

Comparison of ROBIN RNA binders and FDA-approved drugs. A) Kernel Density Estimate (KDE) plots of distributions of six common medicinal chemistry parameters for FDA-approved drugs (grey), ROBIN RNA binders (orange), and compounds from the SMM library that did not score as hits for any RNA (SMM Non-RNA Binders, blue). B) Receiver Operating Characteristic (ROC) curve for classification of ROBIN RNA binders and FDA-approved drugs using LASSO logistic regression. C) Five features with the highest odds ratios identified by LASSO. D) Five features with the lowest odds ratios identified by LASSO.