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. Author manuscript; available in PMC: 2024 Mar 6.
Published in final edited form as: Angew Chem Int Ed Engl. 2023 Feb 6;62(11):e202211358. doi: 10.1002/anie.202211358

Table 1.

Statistics for hit rates of 36 SMM screens classified by nucleic acid structure type. Included are hit rate (average hit rate for oligonucleotide targets in that class of structure) and selective hit rate (average hit rate for oligos, considering only compounds that bind to that target and no others).

Structure Type Count Hit Rate (%) Selective Hit Rate (%)

DNAG4 9 0.45 ± 0.18 0.12 ± 0.15
RNAG4 6 0.78 ± 0.26 0.22 ± 0.15
RNA Hairpin 14 0.48 ± 0.26 0.16 ± 0.12
RNA Pseudokrtot 3 0.85 ± 0.15 0.33 ± 0.07
RNA 3WJ 2 0.79 ±0.18 0.23 ± 0.17
RNA Triple Hélix 2 0.61 ± 0.23 0.21 ± 0.02