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. Author manuscript; available in PMC: 2024 Mar 6.
Published in final edited form as: Angew Chem Int Ed Engl. 2023 Feb 6;62(11):e202211358. doi: 10.1002/anie.202211358

Table 2.

Substructures enriched in selective ROBIN RNA binders. Ten scaffolds and ring structures enriched in selective ROBIN RNA binders relative to SMM Non-RNA binders. Values indicate frequency of occurrence and fold change in binders relative to non-binders.

Substructure Selective
ROBIN RNA
Binders
SMM
NorvRNA
Binders
Fold
Change

graphic file with name nihms-1861925-t0004.jpg 0.31% 0.01% 31.0
graphic file with name nihms-1861925-t0005.jpg 0.31% 0.05% 6.20
graphic file with name nihms-1861925-t0006.jpg 0.62% 0.15% 4.13
graphic file with name nihms-1861925-t0007.jpg 0.31% 0.08% 3.88
graphic file with name nihms-1861925-t0008.jpg 0.31% 0.08% 3.88
graphic file with name nihms-1861925-t0009.jpg 0.47% 0.14% 3.36
graphic file with name nihms-1861925-t0010.jpg 1.09% 0.36% 3.03
graphic file with name nihms-1861925-t0011.jpg 0.39% 0.14% 2.79
graphic file with name nihms-1861925-t0012.jpg 0.31% 0.12% 2.58
graphic file with name nihms-1861925-t0013.jpg 0.39% 0.16% 2.44