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HNSCC: one disease, two distinct tumour microenvironments
| HNSCC type | Carcinogen | Anatomical site | Incidence | Tumour microenvironment |
|---|---|---|---|---|
| HPV-negative HNSCC | Tobacco, alcohol | Oral cavity, pharynx, larynx | Decreased since 2000s | Decreased immune infiltration |
| HPV-positive HNSCC | HPV | Oropharyngeal | Increased since 2000s | Increased immune infiltration |
HNSCC, head and neck squamous cell carcinoma; HPV, human papillomavirus.
