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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: CA Cancer J Clin. 2022 Oct 28;73(2):164–197. doi: 10.3322/caac.21758

Table 8.

Eligibility for Chemoradiation Deintensification Trials

T1-2N1 Included T4 or N3 included Smokers included
RTOG 1016 15
De-ESCALaTE 16 Only N0-N2a if >10PYSH
TROG 12.01 29 Only N0-N2a if >10PYSH
HN002 17 Only <10PYSH
ORATOR2 57
UNC/UF 8283 <10PYSH or >5 yrs abstinence from smoking
ECOG 1308 86
OPTIMA 7879
Univ of CA 87
Quarterback 8889
MSK 30 ROC 137
HN005 Only <10 PYSH

PYSH= pack-year smoking history