Table 2.

5-year time-dependent AUC estimates of the PRS-enhanced model in the GERA European-ancestry participants. The time-dependent AUC estimates (95% confidence interval) of predicted 5-year absolute risk are based on the PRS-enhanced model including age, first-degree CRC family history, sex, endoscopy history and polygenic risk score.

Stratum	AUC (95% CI)	Difference to the lowest AUC in each stratification (95% CI)
Overall	0.73 (0.71, 0.76)	Not available
Age at study entry, years
40–49	0.77 (0.70, 0.84)	10% (2%, 17%)
50–59	0.72 (0.67, 0.77)	5% (−1%, 11%)
>=60	0.67 (0.64, 0.71)	Reference
First-degree CRC family History
Negative	0.73 (0.70, 0.75)	Reference
Positive	0.78 (0.70, 0.86)	5% (−3%, 13%)
Sex
Women	0.73 (0.70, 0.76)	Reference
Men	0.74 (0.70, 0.79)	1% (−4%, 6%)
Endoscopy history
No	0.73 (0.69, 0.77)	Reference
Yes	0.73 (0.70, 0.77)	0% (−5%, 5%)