. Author manuscript; available in PMC: 2023 Sep 6.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2023 Mar 6;32(3):353–362. doi: 10.1158/1055-9965.EPI-22-0817

Table 3.

Sequential model comparison using 5-year time-dependent AUC in the GERA European-ancestry participants. We compared time-dependent AUCs of 5-year absolute risks based on Model 1 (age and first-degree CRC family history) and Model 2 (age, first-degree CRC family history, sex, and endoscopy history) to the proposed PRS-enhanced model (age, first-degree CRC family history, sex, endoscopy history and polygenic risk score) in GERA European-ancestry participants.

Model	AUC	P-value^a
All participants eligible for screening with age^b 45–74 years
Model 1	0.64	<0.001
Model 2	0.64	<0.001
PRS-enhanced model	0.70	Reference
All participants with age^b 40–49 years and having no endoscopy history
Model 1	0.60	0.04
Model 2	0.62	0.05
PRS-enhanced model	0.76	Reference
All participants
Model 1	0.71	0.04
Model 2	0.71	0.01
PRS enhanced model	0.73	Reference

^a.

P-value for comparing the AUC estimates of a reduced model to the PRS-enhanced model.

^b.

Age at study entry.