TABLE 5.

Results of horizontal pleiotropy by the MR-Egger intercept test and MR-PRESSO global test (based on the IVs screened under the genome-wide significance threshold).

Exposure	Outcome	MR-Egger intercept test			MR-PRESSO global test
		Intercept	SE	P-value	RSS obs	P-value
GERD	Anxiety disorders	1.64E−05	0.019	0.999	7.271	0.960
GERD	Depression	−0.032	0.018	0.088	7.839	0.964

GERD, gastroesophageal reflux disease; SE, standard error; RSS, residual sum of squares.