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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Nat Cancer. 2022 Dec 30;4(2):257–275. doi: 10.1038/s43018-022-00489-5

Fig. 4. The HDAC6 score correlates with the response to ricolinostat in other cancer types.

Fig. 4.

(a) Graphic showing the correlation between HDAC6 score and response to ricolinostat in 72 human cancer cell lines. The curve was fitted by stat_smooth algorithm using lm smoothing method and y~log2(x) formula. The correlation coefficient (R) and P value were estimated using two-tailed Spearman correlation test. N=6 independent experiments per cell line and ricolinostat dose. (b) HDAC6 scores were calculated for 1,156 different cancer cell lines available in the CCLE database representing 20 different human cancers and (c) for over 10,000 molecular profiles representing 32 different types of human cancer that have been collected in the TCGA database. For b and c the number of cell line/patient samples is shown for each group on the figure. The center line indicates the median value. The lower and upper hinges represent the 25th and 75th percentiles, respectively, and whiskers denote 1.5x interquartile range. As N we used all independent replicates available in the CCLE and TCGA data sets, precise information for each sample is available in CCLE and TCGA. LAML: Acute Myeloid Leukemia; LIHC: Liver Hepatocellular Carcinoma; UVM: Uveal Melanoma; KIRP: Kidney Renal Papillary Cell Carcinoma; PCPG: Pheochromocytoma and Paraganglioma; DLBC: Diffuse Large B-Cell Lymphoma; ACC: Adrenocortical Carcinoma; UCS: Uterine Carcinosarcoma; KIRC: Kidney Renal Clear Cell Carcinoma; THYM: Thymoma; CHOL: Cholangiocarcinoma; SKCM: Skin Cutaneous Melanoma; CRC: Colorectal Carcinoma; LGG: Brain Lower Grade Glioma; UCEC: Uterine Corpus Endometrial Carcinoma; KICH: Kidney Chromophobe; MESO: Mesothelioma; TGCT: Testicular Germ Cell Tumors; GBM: Glioblastoma; PRAD: Prostate Adenocarcinoma; CESC: Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma; BLCA: Bladder Urothelial Carcinoma; SARC: Sarcoma; OV: Ovarian Serous Cystadenocarcinoma; THCA: Thyroid Carcinoma; ESCA: Esophageal Carcinoma; BRCA: BC; LUAD: Lung Adenocarcinoma; HNSC: Head and Neck Squamous Cell Carcinoma; PAAD: Pancreatic Adenocarcinoma; STAD: Stomach Adenocarcinoma; LUSC: Lung Squamous Cell Carcinoma. (d) Correlation of ranks of HDAC6 score among 22 cancer types between cancer cell lines from CCLE and patient cancer samples from TCGA. The cell lines used for this comparison were the same used in panels b and c (n=patients and cancer lines used in those panels). The curve was fitted by stat_smooth algorithsm using lm smoothing method and y~x formula, and the 95% confidence interval of the regression line is displayed as shaded. The correlation coefficient (R) and P value were estimated using two-tailed Spearman correlation test.